![]() The impact of hemoconcentration on the risk of VTE in a general population has, to our knowledge, not been extensively investigated in prospective studies. 8 – 12 Hematocrit has also been associated with an increased risk of cardiovascular disease and all-cause mortality in a general population. 7 It is well known that subjects with hematocrit levels above the normal range for the population, such as in primary or secondary erythrocytosis, are predisposed to both arterial cardiovascular disease and venous thrombosis. An increase in the hematocrit is associated with increased blood viscosity, 5 reduced venous return, 6 and increased adhesiveness of platelets. 4 Hematocrit, the proportion of blood volume occupied by red blood cells (RBC), is one of the major determinants of blood viscosity. 3Īs Virchow postulated, the risk of VTE is primarily related to hypercoagulability, altered blood flow, or endothelial vascular lesions. 1 Although increasing age, obesity, surgery, trauma, malignancy, immobility, pregnancy, and acute medical conditions are well-known risk factors for VTE, 1, 2 up to 30–50% of cases of VTE have no obvious predisposing factors. ![]() Venous thromboembolism (VTE), manifested as deep vein thrombosis or pulmonary embolism, is a common, multifactorial disease with serious short- and long-term complications and potentially fatal outcome. ![]()
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